Marriage Essay Example Marriage in Britain - Bestessay4u

Marriage in Britain England has become a profoundly metropolitan area in the course of the only remaining century (Hooper-Greenhill, 1999). In this paper, I will reveal insight into the ethnographic patterns of marriage in Britain. So as to do as such, I will utilize my own encounters that I have had during my time in Britain. I had consistently been intriguing in finding out about new societies since I was a kid. Be that as it may, maybe no experience was as astounding as that which I got from coming to Britain. It required some investment to make a few companions, however I was in the long run ready to build up an immense friend network. With the progression of time, I had the chance to go to the weddings of a couple of my companions and partners. Much to my dismay that the experience of going to relationships in the Britain brings unquestionably more assorted variety than one would anticipate. I had the option to see go to Jewish wedding services, Hindu wedding functions and even Muslim wedding services among others. It felt somewhat weird from the outset yet then I understood that the metropolitan culture of Britain has created to a point where the frequency of I unmistakably review that there was one event on which I heard that a couple had run off and gone into the following town to remain until their families were eager to acknowledge their marriage. I felt somewhat abnormal from the outset however then I saw that the individuals around me were not even half as on edge as I might have been. Presently I realize that the frequency of such events is additionally a typical part. The perceptions that I have made by going to wedding functions for companions having a place with various religions and ethnicities has gave me that individuals in Britain regard social decent variety. I saw my British companions moving at my Indian companions wedding with a moving instrument called the dandia. The following week I joined my Egyptian companions doing the eastern bhangra at my British companions wedding. A couple of my companions took uncommon exercises to figure out how to play the bagpipes basically so they could play them at our Irish friend’s wedding; when they discovered that he needed to be near his underlying foundations at his wedding. I currently sit tight for a wedding card to tag along with the goal that I can go to a wedding service. I think notice that relationships in Britain are not confined across societies and ethnicities. During my time in Britain, I have seen people having a place with fluctuating ethnicities getting hitched. I accept that bigotry and bias is a relic of days gone by in Britain since deciding from the assortment in the relationships I have joined in, individuals have gotten more open minded and tolerating than they ever were previously. The way that I have joined in and seen over twelve multi-ethnic relationships is evidence of the way that Britain has genuinely advanced into a current metropolitan locale. It is out of line to finish this paper without expressing that the level of social assorted variety and the acknowledgment that Britain harbors towards social decent variety is really inspiring. Reference List Hooper-Greenhill, E. (1999). The instructive job of the historical center. New York: Routledge. So How Can We Help You? Many understudies get our assistance with assignments consistently. Just by paying a sensible charge, they get work of extra-conventional quality. So let us recognize what we can accomplish for you. Contact us on Live Chat now.

Nocturnal Awakening And Frequent Crying †Myassignmenthelp.com

Question: Examine About The Nocturnal Awakening And Frequent Crying? Answer: Presentation: Nighttime arousing and visit crying scene in little youngsters gives significant difficulties to guardians while thinking about their kids. Sleep time issue and late evening arousing influence around 20 to 30% of babies and little children. This issue starting in early stages frequently persevere in school age as well. This is found to have harmful impact on kids, for example, poor subjective turn of events, temperament issues, forceful conduct and consideration deficiency. This subsequently affects wellbeing and personal satisfaction of kids as well. In the event of guardians, crying scenes and nighttime arousing in kids builds their misery level because of exhaustion and absence of rest (Honaker and Meltzer 2014) Hence, there is a need to discover techniques or mediation to oversee sleep time fits of kids. The examination by Rickert and Johnson (1988) distinguished the mediation of booked arousing as a viable system to lessen and bit by bit dispense with the crying scenes and late evening arousing in small kids. The investigation for the most part assessed the viability of booked arousing by contrasting it and precise disregarding technique. The booked arousing intercession is the business procedure of waking and supporting a youngster 15 to 30 moment before nighttime arousing to aid rest solidification. The development in rest design was examined by implies including a no treatment bunch without the intercession as well. This report fundamentally dissected the examination concentrate by contrasting it and late writing on a similar issue to survey whether such mediation ought to be subsidized or not. Henceforth, the choice for financing the mediation relies upon its basic examination by methods for important CASP instrument Search procedure: To dissect the viability of planned arousing in lessening nighttime arousing in little youngsters, there is a need to audit ongoing examination written works identified with the subject to see if same procedures or different mediations has been proposed for tending to the exploration issue. The primary procedure for looking through the examination article is to incorporate just those articles which have been distributed somewhere in the range of 2007 and 2017. The other incorporation models for articles incorporates they should be peer assessed diary articles written in English and they should cover the methodologies to oversee nighttime arousing in small kids. The pertinent research articles were recovered from the databases like CINAHL, PubMed, Cochrane library and the internet searcher called Google Scholar. The key hunt term utilized in looking through the articles remembered nighttime arousing and crying scenes for little youngsters, intercession for nighttime arousing in newbor n children and systems to address nighttime arousing issues in kids. The consideration rules and explicit inquiry term can assist with inspecting current investigations and assess current intercessions proposed for a similar issue. Writing search: The key discoveries from the survey of writing are as per the following: Creator and date Intercession Key discoveries Honaker and Meltzer (2014). It investigated the impact of conduct mediations on sleep time issue and late evening arousing Practically 94% examinations revealed effectual result and clinical improvement in small kids by utilizing conduct treatment. Bolster was given to intercessions like booked arousing and positive daily practice Meltzer and Mindell, 2014 Conduct intercessions like graduated annihilation, parent instruction, sleep time blurring, planned arousing was assessed for their impact in rest solidification Social treatment brought about progress in childrens rest beginning inactivity and late evening waking recurrence, anyway there is absence of studies that distinguished variables required for accomplishment of treatment. Vriend and Corkum, (2011) Clinical administration of social a sleeping disorder It clarified about various type of intercessions for conduct a sleeping disorder, for example, pharmacological mediation, social treatment and rest medicines. Conduct treatment was seen as the preferred choice treatment for the late evening arousing Werner et al. (2015) The Zurich 3 idea for the administration of rest issue in youngsters. This procedure joins the rest guideline model on presenting normal musicality with changing sleep time with conduct systems. The mediation was found to diminish nighttime wake length of kids and increment night rest term. Cost et al. (2012) Assessment of conduct baby rest intercession to improve newborn child rest Rest intercession has no drawn out effect and guardians can utilize their procedure just for overseeing short to medium term rest issues and maternal wretchedness Basic examination: As the exploration concentrate by Rickert and Johnson (1988) depends on randomized controlled technique, the CASP device for randomized controlled preliminary has been applied for basically evaluating the articles. The consequences of the examination are as per the following: Legitimacy of the consequences of the investigation Nearness of centered issue in the investigation: Rickert and Johnson (1988) gave away from of the engaged issue in the examination by unmistakably expressing the primary motivation behind research. The fundamental point was to assess the viability of planned arousing and methodical disregarding systems (intercession) for diminishing arousing and crying scenes in babies and little youngsters (populace). Consequently, the fundamental mediation was planned arousing and efficient overlooking and the comparator was no treatment condition Procedure of assignment: In RCT examines, irregular allotment process is expected to haphazardly appoint members to treatment and control gathering. At the point when this procedure is done accurately, it is compelling in lessening predisposition in the framework. In this manner, the two basic parts of the irregular allotment process is creating arbitrary arrangement and covering the treatment before patients have been doled out to explicit gatherings (Dettori 2010). The members for the randomized controlled preliminary included 33 kids with normal age of 20 months and they were selected by means of nearby paper promotions. All the kids were economy doled out to treatment gathering and control bunch before home visit (Rickert and Johnson 1988). Thus, it is affirmed that allotment arrangement were hidden from scientist and patients as guardians became more acquainted with about their doled out gathering simply after information was gathered in regards to every childs day by day plan (span of time wakeful for the afternoon, taking care of time, term when youngster precipitously woke up and cried and strange circumstances upsetting everyday practice) for 9 nine weeks. Treatment of patients who entered the preliminary: To survey whether all members who entered the preliminary were appropriately represented its decision or not, it is fundamental that total follow up of patient is done and specialist investigate the result in members allocated to explicit gathering. In this unique situation, peculiarities have been found in the treatment of gathering in the investigation. For example, from the outset kids were haphazardly doled out to control, booked arousing or orderly disregarding gathering. In any case, the same number of kids dropped out in the middle of, just 33 members stayed for the investigation out of 56. To guarantee that all members were broke down in their appointed gathering, guardians were approached to report seven days preceding treatment. This aided in keeping up standard information for the examination. The upkeep of benchmark information mirrors the legitimacy and straightforwardness of the investigation as it helps in viably deciphering the examination results (Deke and Puma 2013) . Blinding to treatment Blinding in randomized controlled preliminary is finished by having systems that keeps members and assessors from knowing which intercession was given to them. Be that as it may, it is difficult to accomplish blinding in contemplates, on the grounds that for assessing the result of the investigations, dynamic commitment of members is required. In the examination concentrate by Rickert and Johnson (1988), all kids and their folks were arbitrarily allocated to treatment. This implies distribution to treatment was disguised from them, anyway it can't be said that they were blinded to treatment as well. They were arbitrarily alloted to control and the two mediation gathering and members became more acquainted with about their doled out gathering simply after information identified with the historical backdrop of unconstrained arousing in every kid were gathered. Thus, open marking in this examination was seen which didn't satisfied the blinding standards and this may prompt biasness as w ell. In a comparable RCT study done to assess the adequacy of conduct rest mediation, babies were chosen based on guardians detailed rest issue, anyway the distinction in come closer from the above investigation was that allotment was covered and just scientists however not guardians were blinded to bunch assignment (Price et al. 2012). Likeness of the gatherings toward the beginning of the preliminary While assessing the nature of a RCT study, the likeness of the gathering toward the beginning of the preliminary is signified by gauge factors, for example, age, sex, social class, training and wellbeing status. Keeping these standard parameters comparable is basic for keep up the legitimacy of the investigation since baselines factors additionally impact study result and impact of mediations (Higgins et al. 2011). Rickert and Johnson (1988) kept up the likeness of gathering toward the beginning by taking kids in the age gathering of 6 to 54 months. Notwithstanding, biasness in benchmark factors was that equivalent social factor was not kept up. For example, there were single parent families just as two-parent families. Distinction in level of training of guardians was additionally observed which may have extraordinary effect on the investigation result. Such benchmark enlistment isn't kept up in numerous different investigations as well. Equivalent treatment of the gathering: Equivalent treatment of the gathering in randomized controlled preliminary is kept up if scientist can recognize some other factor

Acute Stress Disorder Symptoms and Link to PTSD

Acute Stress Disorder Symptoms and Link to PTSD Acute stress disorder and post-traumatic stress disorder (PTSD) often go hand-in-hand. This is because a diagnosis of PTSD cannot be made until at least one month after the experience of a traumatic event. Yet, it is likely that people may begin experiencing PTSD-like symptoms soon after a traumatic event. The 4th edition of the Diagnostic and Statistical Manual of Mental Disorders describes these PTSD-like symptoms occurring within one month of a traumatic experience as Acute Stress Disorder (ASD). Overview of PTSD Symptoms The symptoms of ASD are similar to those of PTSD except they occur soon after the experience of a traumatic event. ASD symptoms include the re-experiencing, avoidance, and hyperarousal symptoms of PTSD. For example, a person with ASD may experience frequent thoughts, memories, or dreams about the traumatic event. They may also constantly feel on-edge or try to avoid reminders of the event. ASD also includes symptoms of dissociation. Dissociation is an experience where a person may feel disconnected from himself and/or his surroundings. Dissociation may range from temporarily losing touch with what is going on around you (such as what happens when you daydream) to having no memories for a prolonged period of time (blanking out) and/or feeling as though you are outside of your body. You may feel like you are watching yourself as if you were another person. Coping with Dissociation and Flashbacks in PTSD Diagnosis It is normal to experience certain stress-related symptoms following the experience of a traumatic event. Therefore, to be diagnosed with ASD, a person must meet certain requirements (or criteria). These requirements are described by the DSM-IV and are provided below: Criterion A A person must have experienced a traumatic event where both of the following occurred: The person experienced, witnessed, or was confronted with an event where there was the threat of or actual death or serious injury. The event may also have involved a threat to the persons or another persons physical well-being.The person responded to the event with strong feelings of fear, helplessness, or horror. Criterion B The person experiences at least three of the following dissociative symptoms during or after the traumatic event: Feeling numb or detached or having difficulties experiencing emotions.Feeling dazed or not entirely being aware of surroundings.Derealization, or feeling as though people, places, and things are not real.Depersonalization or feeling separated and detached from oneself.Dissociative amnesia, or being unable to recall important parts of the traumatic event. Criterion C The person has at least one re-experiencing symptom, such as having frequent thoughts, memories, or dreams about the event. This may take the form of flashbacks in which the event is experienced as if it were happening against, or nightmares, in which the event is re-lived in some form. Criterion D The person attempts to avoid people, places, or things that remind him or her about the event. Criterion E The person has hyperarousal symptoms, such as feeling constantly on guard or jumpy, having difficulties sleeping, problems with concentration, or irritability. Criterion F The symptoms described above have a great negative impact on the life of the person experiencing them, interfering with work or relationships. Criterion G The symptoms last for at least two days and at most four weeks. The symptoms also occur within four weeks of experiencing the traumatic event. Criterion H The symptoms are not due to an illness or other medical condition, medication being taken, or alcohol/drug use. ASD and PTSD ASD is a serious condition. People with ASD are at greater risk for eventually developing PTSD. Because of the dissociation symptoms of ASD, a person may not be able to recall important parts of the event, as well as the emotions they experienced. This might interfere with a persons ability to fully process the impact of the event and their emotions about the event, hindering the recovery process. Post-traumatic stress disorder (PTSD) is a difficult-to-treat and heart-wrenching condition that can greatly impact the peace and well-being of survivors of trauma. It is hoped that by being able to identify acute stress disorder through these criteria, those who are at risk of developing PTSD will be better identified and monitored so that they can be helped before their symptoms progress to PTSD. There has been debate over how well ASD can predict  PTSDâ€"most people with ASD go on to develop PTSD, but many people diagnosed with PTSD do not have a history of prior ASD. Yet, in addition to having predictive value for PTSD, ASD is a serious condition deserving of thoughtful care and treatment in its own right. If you think you may have ASD, it is important that you meet with a mental health professional trained in assessing and treating ASD. The earlier you recognize and address these symptoms, the greater the chance you have of preventing the development of PTSD, and the greater the chance that you can get started right away in coping with the symptoms you currently have. How to Find a Therapist That Is Right for You

Acute Stress Disorder Symptoms and Link to PTSD

Acute Stress Disorder Symptoms and Link to PTSD Acute stress disorder and post-traumatic stress disorder (PTSD) often go hand-in-hand. This is because a diagnosis of PTSD cannot be made until at least one month after the experience of a traumatic event. Yet, it is likely that people may begin experiencing PTSD-like symptoms soon after a traumatic event. The 4th edition of the Diagnostic and Statistical Manual of Mental Disorders describes these PTSD-like symptoms occurring within one month of a traumatic experience as Acute Stress Disorder (ASD). Overview of PTSD Symptoms The symptoms of ASD are similar to those of PTSD except they occur soon after the experience of a traumatic event. ASD symptoms include the re-experiencing, avoidance, and hyperarousal symptoms of PTSD. For example, a person with ASD may experience frequent thoughts, memories, or dreams about the traumatic event. They may also constantly feel on-edge or try to avoid reminders of the event. ASD also includes symptoms of dissociation. Dissociation is an experience where a person may feel disconnected from himself and/or his surroundings. Dissociation may range from temporarily losing touch with what is going on around you (such as what happens when you daydream) to having no memories for a prolonged period of time (blanking out) and/or feeling as though you are outside of your body. You may feel like you are watching yourself as if you were another person. Coping with Dissociation and Flashbacks in PTSD Diagnosis It is normal to experience certain stress-related symptoms following the experience of a traumatic event. Therefore, to be diagnosed with ASD, a person must meet certain requirements (or criteria). These requirements are described by the DSM-IV and are provided below: Criterion A A person must have experienced a traumatic event where both of the following occurred: The person experienced, witnessed, or was confronted with an event where there was the threat of or actual death or serious injury. The event may also have involved a threat to the persons or another persons physical well-being.The person responded to the event with strong feelings of fear, helplessness, or horror. Criterion B The person experiences at least three of the following dissociative symptoms during or after the traumatic event: Feeling numb or detached or having difficulties experiencing emotions.Feeling dazed or not entirely being aware of surroundings.Derealization, or feeling as though people, places, and things are not real.Depersonalization or feeling separated and detached from oneself.Dissociative amnesia, or being unable to recall important parts of the traumatic event. Criterion C The person has at least one re-experiencing symptom, such as having frequent thoughts, memories, or dreams about the event. This may take the form of flashbacks in which the event is experienced as if it were happening against, or nightmares, in which the event is re-lived in some form. Criterion D The person attempts to avoid people, places, or things that remind him or her about the event. Criterion E The person has hyperarousal symptoms, such as feeling constantly on guard or jumpy, having difficulties sleeping, problems with concentration, or irritability. Criterion F The symptoms described above have a great negative impact on the life of the person experiencing them, interfering with work or relationships. Criterion G The symptoms last for at least two days and at most four weeks. The symptoms also occur within four weeks of experiencing the traumatic event. Criterion H The symptoms are not due to an illness or other medical condition, medication being taken, or alcohol/drug use. ASD and PTSD ASD is a serious condition. People with ASD are at greater risk for eventually developing PTSD. Because of the dissociation symptoms of ASD, a person may not be able to recall important parts of the event, as well as the emotions they experienced. This might interfere with a persons ability to fully process the impact of the event and their emotions about the event, hindering the recovery process. Post-traumatic stress disorder (PTSD) is a difficult-to-treat and heart-wrenching condition that can greatly impact the peace and well-being of survivors of trauma. It is hoped that by being able to identify acute stress disorder through these criteria, those who are at risk of developing PTSD will be better identified and monitored so that they can be helped before their symptoms progress to PTSD. There has been debate over how well ASD can predict  PTSDâ€"most people with ASD go on to develop PTSD, but many people diagnosed with PTSD do not have a history of prior ASD. Yet, in addition to having predictive value for PTSD, ASD is a serious condition deserving of thoughtful care and treatment in its own right. If you think you may have ASD, it is important that you meet with a mental health professional trained in assessing and treating ASD. The earlier you recognize and address these symptoms, the greater the chance you have of preventing the development of PTSD, and the greater the chance that you can get started right away in coping with the symptoms you currently have. How to Find a Therapist That Is Right for You

Argumentative Essay On Killing Bugs - 1050 Words

Argumentative Essay The morality of killing bugs has been a big discussion for many years. But for Arvind, the answer is quite obvious. One day when he was brushing his teeth he saw something black in the sink. When he realized it was a bug he quickly plugged the sink, cut off the water, grabbed a piece of toilet paper, and fished the bug out of the sink. At first, he thought the bug had died, but then he saw it start to move. He had saved the bug’s life! â€Å"I was filled with relief and joy and my happiness surpassed the level of my sadness from only a few seconds before†¦The rest of that day I was on a sheer high†(Evalia). This experience had a big impact on how he viewed life. â€Å"†¦it shows that we have a deep compassion within us and it†¦show more content†¦Many animals would die because bugs are their main food source. â€Å"Between 50 and 90 percent of the human diet by both volume and calories, depending on the country, comes directly from flowering plants †(Hadhazy).Lots of animals eat bugs so if bugs were gone, many of these animals would die off. Also, many bugs are decomposers and help get rid of dead animals, plants, etc. â€Å"The group of organisms called decomposers forms the final link in the food chain. They break down dead animals and plants and return vital nutrients to the soil†(Batema). So decomposers are important because they return the nutrients, needed for healthy plants, back into the soil. Vegans always talk about how people shouldnt kill animals. Then why do vegans never say anything about bugs? Bugs are animals too. â€Å"Every human being directly kills bugs just by walking - and indirectly kills bugs by renting and buying constructed housing. Yet Ive never heard even a strict vegan express a word of moral condemnation for this mass animal killing†(Caplan). PETA claims â€Å"the determination of when lethal defense against insects and animals is acceptable must be judged on a case-by-case ba sis, taking into account the level of the threat and the alternatives that are available†(PETA). So PETA is basically saying that the morality of killing bugs is judged by the situation. So basically, if a person killed 100 people it would depend on the situation if it was okay or not. It doesntShow MoreRelatedHamlet; Tragic Hero3618 Words   |  15 Pages   Argumentative/Persuasive Essay                   Hamlet; The Tragic Hero            Ã‚  Ã‚      In many plays there is always one person that is the tragic hero. They always possess some type of tragic flaw that in turn leads to their tragic deaths. In the Shakespearean play HamletRead MoreLogical Reasoning189930 Words   |  760 Pageswouldnt even have been allowed into the park or at least you would have been warned in person. The sign said the station is out of sterilization tablets, implying that sterilizing the water will make it safe. Safe in what sense? Sterilizing means killing or removing all the living organisms, but not necessarily all the harmful chemicals. If you were to sterilize water containing gasoline, that wouldnt make it safe to drink. So, the problem is definitely the microorganisms. Now surely the rangersRead MoreTop 1 Cause for Project Failure65023 Words   |  261 Pagescases I am a stakeholder but in the latter I am an active stakeholder. The end user is ALWAYS a customer regardless their level of involvement. †¢ [pic] Robert Lewis President at IT Catalysts, Inc. Jim ... At the risk of sounding argumentative, I ll state two points with certainty: 1. End-users aren t customers. As a matter of definition (admittedly, our definition), customers are the people who make or influence buying decisions. They might or might not be the people who use theRead MoreDeveloping Management Skills404131 Words   |  1617 Pagesthrough the air. Unless you can fix on something that is not changing—for example, the ground or the stars—it is impossible to fly the plane. Tragically, investigators found that John F. Kennedy Jr. unknowingly flew his plane into the Atlantic Ocean killing himself, his wife, and his sister-in-law because he lost sight of land and, consequently, lost perspective. He became unable to manage change because he did not have an established, unwavering point that helped him maintain his bearings. We make sense

Essay on Hamlet V Don Quixote - 1398 Words

Tiffany To COM 002 Josh Waggoner Dec 3, 2008 Word Count: 1359 ‘Madness’ used as Justification Madness has become a revolutionary standard in literary work throughout the centuries. Shakespeares Hamlet and Miguel de Cervantes Don Quixote both contain characters that use madness to excuse their actions in their lives respectively. Hamlet, filled with vengeance, seeks justice for the unexplained sudden death of his father Hamlet Senior. Don Quixote, a knight that is entranced by tales of chivalry has decided to live his life devoted towards gaining honor through his encounters. Hamlet and Don Quixote alike share the character roles of convincing those around them that they have gone mad.†¦show more content†¦Not only does it not accomplish anything, but it also aids to Polonius and King Claudiuss suspicion of Hamlets madness as a result of his love for Ophelia. Hamlets madness takes a toll on the reactions of the King and Queen. He uses the various players to display a show for the court testing the reaction of King Claudius. Other officials in the court may see this p lay as inappropriate because, it indirectly accused the King of murder. However, Hamlet uses his elaborate excuse of insane that he is not aware of this obvious connection. In the scene with Queen Gertrude and Hamlet in the bedroom Hamlet reacts instinctively. Stabbing the curtain when he hears a stir, he stabs Polonius to death. This can be compared to Hamlets missed opportunity of killing King Claudius while he was seen in his bedroom. Hamlet killed Polonius on accident, although when given the chance to avenge his fathers death he retreats. It is apparent that he is afraid to act rationally, instead choosing to acting without reason hoping to accidentally gain vengeance for his father. The amateur knight Don Quixote on the other hand, repetitively acts stubborn and uncooperative despite his squire Sanchos attempts to warn his master about his misconceptions. Before journeying on his adventure, Don Quixote dubs a farm girl which he had a crush on to be his lady, Dulcinea del Tobos o. First stopping at an unnamed Inn, Don Quixote asks to beShow MoreRelatedAnalysis Of Miguel Of Cervantes Saavedra1581 Words   |  7 PagesAbstract Miguel of Cervantes Saavedra was a Spanish writer who lived in the late 1500’s in the Spanish Empire at the time of Charles V. This first part of this novel was published in 1605 and the second part in 1615 as it was very common at the time. Cervantes was a Spanish soldier when he was a young lad. Cervantes accomplished a very audacious life and had a lot of weird and odd experiences like getting thrown into a Turkish prison or losing his left hand in the Battle of Lepanto, giving him theRead MoreAge of Doubt In Europe in the 16th Century878 Words   |  4 PagesDoubt, Age of Uncertainty†. The wars going on throughout Europe through this era were claiming territories through conquest, marriage alliances, or inheritance agreements on the basis of religious uniformity (429). In the 1540’s Germany’s Charles V set into motion attacks against the German princes who were proponents for Lutheran worship. This failed due to the financial taxing of the war Germany had going on with France as well as the fear that the oppression of the Lutheran prices would be similarlyRead MoreCrossing the Chasm76808 Words   |  308 Pagesedition v 1. October 2001 ISBN 0-06-018987-8 The original hardcover edition of this book was published in 1991 by HarperBusiness, a division of HarperCollins Publishers. 10 9 8 7 6 5 4 3 2 1 To Marie Contents PREFACE TO THE REVISED EDITION FOREWORD ACKNOWLEDGMENTS PART I Discovering the Chasm INTRODUCTION If Bill Gates Can Be a Billionaire 1 High-Tech Marketing Illusion 2 High-Tech Marketing Enlightenment PART II Crossing the Chasm 3 The D-Day Analogy v vi

Same Sex Marriage Should Be Legal - 2381 Words

In 2015, same-sex marriage has been ruled legal in all 50 states but that wasn’t always the case. Gay Marriage has been a conflict since the Roman Empire. In 342 AD Christian emperors Constantius and Constans issued a law in the Theodosian Code prohibiting same-sex marriage in Rome and ordering execution for those who married. Marriage existed between a male Roman and female Roman citizen, so that marriage between two Roman males (or with a slave) would have no legal standing in Roman law. In the United States, same-sex marriage is recognized by the U.S. federal government and is legal in 35 U.S. states. Most Americans live in a jurisdiction where same-sex couples can legally marry. Same-sex marriage in New York became legal in July 24, 2011. New York is the seventh state to license same-sex marriage. As an institution that has become more egalitarian and is considered to be a human right, marriage should be made available to couples regardless of gender. New York Gov. Andrew Cuomo signs a bill legalizing same-sex marriage, making the Empire State the sixth in the nation to allow gay and lesbian couples to wed, in 2009. In 2012, Barack Obama becomes the first sitting president to announce his support for same-sex marriage. Voters in Maine, Maryland and Washington state approve laws legalizing same-sex marriage, becoming the first states to do so through popular votes. In 2013, The Supreme Court strikes down part of the federal Defense of Marriage Act, requiring theShow MoreRelatedSame Sex Marriage Should Be Legal1288 Words   |  6 Pages Marriage is not precisely the same as it used to be interpreted. For example, women used to be their husband’s property. Sometimes the women were forced to marry whoever their parents wanted them to marry and most of the time they couldn’t leave the marriage. Nowadays women have more freedom. They can vote, they can run their own business, and they can marry whichever man they want to. 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Those words historically indicate that until the death of a spouse, that couple shall remain together. Who should be able to determine whom that spouse is for that person? Some people judge others for their sexuality and how it is affecting them, but they never stop andRead MoreSame Sex Marriage Should Be Legal1144 Words   |  5 PagesGay Marriage There are many issues the revolve around same-sex marriage. Many issues like: Whether same-sex should be legalized and should there be an amendment on same-sex marriage? There are multiple side to view this, but gay marriage but in my opinion gay marriage is socially accepted. it should be legal and it does affect American teens in a broad spectrum of ways. There have been a lot of issues on whether or not same-sex marriage should be legal or not. According to Burns, â€Å" The unionRead MoreSame Sex Marriage Should Be Legal998 Words   |  4 PagesSame sex marriage ought to be legalized on the grounds that it is uncivilized and unmerited. Marriage is a commitment between two people that cherish one another. In almost every country and culture, marriage is a commitment of loyalty and love. Marriage is an authority contract gathering two individuals together, furnishing them with profits of holy matrimony such as tax cuts and clinical privileges. The debate throughout most countries today is whether or not the rights of these profits and commitmentsRead MoreSame Sex Marriage Should Be Legal1659 Words   |  7 Pages Same-sex couples can hardly remember a time where they were not fighting for their right to marriage in the United States. After several court cases, California Proposition Six, and their struggle against the Defens e of Marriage Act (DOMA), same-sex couples found their way into U.S. society. Many misguided studies appealed to those opposing same-sex marriage, but after several years of integrating in society, same-sex couples found the support they were looking for. Before the Supreme CourtRead MoreSame Sex Marriage Should Be Legal899 Words   |  4 Pages In the United States, same sex marriage became legal nationwide on June 26, 2015, when the United States Supreme Court overruled the court in favor of same sex freedom and marriage. The victory of same sex marriage came to be recognized from the Obergefell v. Hodges case which was submitted when an American Ohio man was denied and regretted to get his name on his late husband’s death certificate. Same sex marriage has been a controversial social issue in the United States for several decades. SinceRead MoreSame Sex Marriage Should Be Legal1491 Words   |  6 PagesSame sex marriage is one of the most debatable issues in the modern world. Marriage has been accepted as the social union between a man and a woman for the past thousand years. Homosexuality was viewed with scorn, and marriages among same sex couples were prohibited in most cultures across the globe. However, gay relationships are slowly obtaining acceptance, as homosexuals have come to be expressive in fighting their rights to marry in the early 90’s. As homosexuality grows in acceptance in theRead MoreSame Sex Marriage Should Be Legal892 Words   |  4 PagesLove Same sex marriage is now allowed in all states across the country. But it took years and years for this â€Å"issue† to be finally laid to rest. The first state to legalize same-sex marriage was Massachusetts in 2004. There was not a last state to legalize gay marriage. The supreme court realized how many states were now legalizing it, so they just had all of the states left legalize it as well. ProCon.org supplies information that â€Å"Twenty-six states were forced to legalize gay marriage becauseRead MoreSame Sex Marriage Should Be Legal2253 Words   |  10 Pages1776). The recognition of same-sex marriage is an issue influenced by numerous factors, and debates continue to arise over whether people in same-sex relationships have the right to marriage. Marriage provides many benefits, legally, financially, and personally. Same-sex marriage can open up those in same-sex relationships to tax benefits and financial demands comparable to those afforded to and required of peo ple in opposite-sex marriages. Same-sex marriage also gives them legal protections, such as

Syria Essay Example For Students

Syria Essay SyriaCultural History: The modern state of Syria was not established until 1946, after the Second World War, but it is a land, which has been inhabited since ancient times. Archaeologists have unearthed evidence of habitation dating back to about 5000B.C. and Damascus is probably the worlds oldest continuously inhabited city. Greater Syria, a land area incorporating Lebanon, Israel, Jordan and present-day Syria, was the site of much conflict and conquest throughout the days of the Ancient World. This conflict has continued throughout the Middle Ages and into modern times. The Egyptians, Babylonians, Hittites have successively ruled ancient Syria, Chaldeans and Persians. It became part of Alexander the Greats empire in 333B.C. when one Alexanders generals founded the city of Antioch as its capital. Struggles between the Seleucids and the Ptolemies of Egypt followed, until 64B.C. when Syria became a province of the Roman Empire. Following the decline and collapse of the Romans and the division of the empire in the 4th century A.D., Syria became a Byzantine province and remained so for almost two and a half centuries. Cultural Identity: Syrian Arab Republic Principal cities include DAMASCUS (the capital) and ALEPPO. Most Syrians are Arabic-speaking Muslims, mainly Sunnite with significant Alawite and Druse minorities; there are also Kurds, Armenians, and CrictinsAbout 10% of the People are Christian, mainly orthodox. Arabic is the official language. Power distance: Syrias government has a lot of power with in. Comparing to other countries Syria has no power because its considers poor society. There are two class systems, its either poor, or rich which would be working with the government. Syria does not have any kind of programs that would take care of the unweallthy family the only choice they have is to go to mosques and beg for food. Unemployment is very high and it keeps on going higher for the poor level. Other Arabic countries come to Syria during summer because its known to be very cheap. Values: Syrians mostly value their kids. They believe the better the parents take care of the kids the better they turn out and in return the kids have to take care of their parents when they get older. Thats the reason they have a lot of them. -Another thing they value is friendship. Arabic girls are not allowed to have a lot of friends because that gives her a bad reputation of knowing every body been every wear. The bad thing about that is, girls are suppose to be unknown to others except their husband they are like daemons if any body breaks them they can never be fixedGreeting and Leaving-takings: Marahaba or in a Muslim way al-salam el-aucom which means hi or hello. A person would most commonly greet others or, when a person enter a room to inform the others that he is coming for that reason the ladies needed to put on their scarfs on their head. In Syria when the guy greets a guy he shakes his hand and if he is very close to him he would kiss him once on ever cheek. When ladies greet each other they always kiss each other on the checks under any circumstances. When it comes to men greeting a woman or vise-versa they just shake hands unless they are relatives they greet with the kissing one the cheek. Politeness and expressing gratitude: Syrians are very open, nice and they like to start conversation about each others life, past, and present. They always like to hear your side of the story then they try to relate with it from their experience. Every time you mention something good they say mashalah which is good for you and of its bad they say wlyalaamty that means cussing the person who did wrong or them selfs if there is no Celebration and Holidays: Syrians mostly celebrate wedding at fancy hotels not Churches a day after the ceremony that takes place at the house. Ramadan (Dec 6) fasting for a month the teaches them o think of others when their hungry. Eid Al Fitr (8 Feb), 3 days thats when Muslim people celebrate eating again, and some try to go to mekeh in Saudi Arabia for omra so they can pray. Mothers day (march 21). Eid Al Adha (17 Apr), 4 days. This holiday relatives usually visit each other brings the family together. Islamic New Years Day (8 May) thats when the quran w as introduced to the Muslims. Only Muslims celebrate by going to the mosque. Prophets Birthday 17Jul. This is a holidaythat no one takes in concretion its not know because its against the Muslim religion to celebrate birthdays. Its only connected a holy day. Christmas (25 Dec) only Christmas celebrate it among them selves. Reaction Paper EssayTopic of conversation: American should avoid talking about business out side of business spatially to family members. Syrian men favorite topic is news and what happen In the world other then Syria because they are not allowed to talk about Syria or the government of Syria because that could get killed. Syrian women like to talk about fashion, food, and each others friends. For example did you hear what happened to soPoliteness: Americans are viewed to be as shy and dont like talking. Syrians dont say thank you and have a nice day they just stop at bye. Tipping and Service: there is tipping in Syria to the waiter who followed you around the whole time your have lunch or dinner. Approximately $1.00. and there are no taxes. In a restaurant customers dont leave right after the meal like they do in America, thats when they take time to talk about their day or any thing else. Table Matters : Syrians dont have any table matters to her then having lunch at 2:00 PM and dinner at 10:00 PM as a family. Complement: Americans should give their opinion on every thing they see and occasionally complement. Syria is use to travelers from all over the world so if you have any questions just ask there always would be some nice to give you an answer. Telephone and Electricity:Syria dose not have any pay phone, if some one wants to use the phone they would have to go into a liquor store. The electricity is 250 volts AC. Dont assume That men walking arm in arm or hand in hand are homosexual. In many Middle Eastern countries, men are much more physically affectionate with their male friends and relatives than men are in the WestDo be careful at security checkpoints when traveling inside Syria. Move slowly and obey the authoritiesDont expect your phone conversations to be private (the phones may be bugged) Do compliment Syrias strides in developmentDont point at people or use your hands to give direction, as to do so is rude. Also, be careful that the sole of your shoe doesnt show when youre sittingDo make appointments and be on time, but dont be offended by a lack of punctuality by others. Also, dont be offended if the person youre meeting for business conducts other business during your appointmentDont show irritation when everythi ng stops five times a day for prayersDo shake hands and say marha-bah,A.H Hourani . (1954). Syria and Lebanon, Oxferd University pressTabitha Petran . (1972). Syria. Praeger Publishers IncVolney, G. F. C. (1987), Travel through Syria and Egypt, 2 vol., London press Malcolm B. Russell M. Islamica B, (1985), The first modern Arab state, Cambridge University Presshttp://arab.net/syria/history/sy_ancient.htmlhttp://msn.directhit.com/fcgi-bin/DirectHitMSNa.fcg?fmt=htmlqry=Syria+Governmentattrib=1http://home.msen.com/burnett/96syria.htmBibliography:

How To Stay Safe Around Your University Campus This Autumn/Winter

University can be the best part of your life. Letting certain things spoil that due to carelessness or a lack of responsibility can seriously damage your time in higher education. As the days get shorter and the nights darker, here at Essay Writing Service we know just how crucial staying safe and looking after yourself around campus is. Always walk in open spaces at night Be aware of your surroundings no matter what the situation and avoid walking in unfamiliar places at night. Open spaces which are likely to have more people around tend to be safer; if something happens someone is likely to see and come to help. Avoid walking through unlit public areas You may always have a route into campus through a park or wooded area but this should be off limits at night. Many wooded areas tend to be poorly lit and provide coverage for any incidences that might occur. Plan a route that will take you through a thoroughly lit area. Try to walk home in a group It can be easy to lose your friends when you are on a night out but having an action plan to stick together is a must. If someone tries to leave the group, make sure they don't go alone. People that move in groups are less likely to be the victims of any offense compared to those that are alone. Stay in touch with friends/family If you are in a situation where you are on your own, whether you have left or lost your group of friends, or are travelling back from somewhere at night, stay in touch with people. A quick message to a friend or family member to tell them you are safe goes a long way. Don't cause any unnecessary worry. Make phone-calls if necessary to help you feel more comfortable and safe when alone. Keep an eye on your locks Student areas are particularly prone to burglaries or crime so be vigilant with your locks. Always keep windows and doors locked when you leave the house, if you are home alone, and at night. If there are any problems with your locks report them immediately to your landlord to get them fixed straight away. Many landlords present keys with a label of your house number attached; it is a good idea to remove this in case you lose your keys. Place your belongings out of sight Leaving electrical or expensive equipment on show when you are not around the house is a temptation to the opportunist. As well as keeping windows and doors locked, consider putting your things out of plain sight. Insurance is a good thing to have at university because things can break or go missing all the time; Endsleigh offers tailored student insurance packages to suit your needs. (via NHS) Know your limits and be alcohol wise Going out with your friends and socialising is a big part of the university lifestyle. Being careless though can ruin an entire night and can often have very dangerous consequences. When you're at a bar, club or pub always keep an eye on your drink and refuse drinks from strangers. With the NHS announcing that every year hundreds of people are thought to be the victims of drinks spiking, as well as the increase in date rape drugs and rape cases, it is vital that you always keep an eye on your drink. Know your limits too and don't be pressurised into drinking something you don't want to. Have fun but stay safe. Don't invite strangers back Meeting someone when you are out, particularly under the influence of alcohol, can give you only a limited knowledge of that person. As trusting as they may seem, many people will take advantage of vulnerability. Whether you feel comfortable with them or not, don't invite a stranger back to your house. If you are interested in seeing that person again, arrange to meet somewhere public. Save emergency or late night numbers Have the numbers for your local services, safety watches or wardens saved in your phone. Trying to fumble around for a number that isn't there is the last thing you want. Know the late night services and schedules of your public transport options; if you are travelling alone on public transport don't sit in an empty carriage. Keep late night taxi numbers to hand too; never get into an unlicensed taxi though and always check that it is the correct vehicle before you enter. Make sure your hands are free If you are obstructed by an armful of books or other possessions you are an easy target. Have your hands free when you are walking or travelling alone at night. Many universities or self-defence programmes would advise carrying your keys in one hand just in case you need to defend yourself. Making a phone-call to feel safer is a good option but be aware of what is going on around you whilst you are on your mobile, and keep your other hand free. Listening to music or using a headset isn't recommended either as you are less likely to hear someone coming towards you. Above all here at Essay Writing Services we want you to get the most out of university. Make your university time memorable but in all the rights ways by following our guidance and taking particular care when you are out at night. For more tips and help on how to survive your first term at university, head to our blog. Our professional experts can help with any areas of academia from proofreading or advising on essays, to assisting with dissertations. Don't hesitate to contact us today.

16 Sweet Quotes About First Love

16 Sweet Quotes About First Love The first brush of love is a delicious feeling. You feel fresh energy surging in your body, and you become constantly aware of your own appearance, attitude, and behavior. The effect of new love may last for the courtship period, where both partners put their best foot forward. You enjoy the romantic overtures, the subtle body language, and the anticipation of passionate love. You could fall in love many times during the course of a lifetime, but the first rush of love always holds a special place in our hearts. The novelty of the feeling, like the first drops of dew on an untouched leaf, makes it special and unforgettable. These first love quotes develop on the theme of this treasured rush called first love. George Bernard Shaw First love is a little foolish and a lot of curiosity. Branislav Nusic First love is dangerous only when it is also the last. Rosemary Rogers First romance, first love, is something so special to all of us, both emotionally and physically, that it touches our lives and enriches them forever. Benjamin Disraeli The magic of first love is our ignorance that it can never end. Thomas Moore No, theres nothing half so sweet in life as loves young dream. Alfred Lord Tennyson In the spring a livelier iris changes on the burnished dove;In the spring a young mans fancy lightly turns to thoughts of love. Leo Buscaglia Love is always bestowed as a gift - freely, willingly, and without expectation... We dont love to be loved; we love to love. Blaise Pascal We conceal it from ourselves in vain: we must always love something. In those matters seemingly removed from love, the feeling is secretly to be found, and man cannot possibly live for a moment without it. Nietzsche Love is the state in which man sees things; most widely different from what they are. William Shakespeare As sweet and musicalAs bright Apollos lute, strung with his hair;And when Love speaks, the voice of all the godsMakes heaven drowsy with the harmony. Lady Murasaki The memories of long love gather like drifting snow, poignant as the mandarin ducks who float side by side in sleep. Leo Buscaglia The heart is the place where we live our passions. It is frail and easily broken, but wonderfully resilient. There is no point in trying to deceive the heart. It depends upon our honesty for its survival. Richard Garnett Sweet are the words of love, sweeter his thoughts:Sweetest of all what love nor says nor thinks. Bayard Taylor The loving are the daring. Francois Mauriac No love, no friendship, can cross the path of our destiny without leaving some mark on it forever. Alexander Smith ï » ¿Love is but the discovery of ourselves in others, and the delight in the recognition. Rekindle the Romance in Your Relationship First love is not just for first-time lovers. You can even feel the magic with your spouse. Some  couples  have claimed that every time they stay apart for a while, their reunion is as if they just met on a first date. Some  married couples  renew their  marriage  vows to rekindle the old flame. Have you felt the same way about your partner? If you havent, you need to rekindle the  romance and walk down memory lane. Visit romantic cities like Paris or Rome, and  fall in love  in the presence of the gods of love.

Merger, Acquisition, and International Strategies Essay - 9

Merger, Acquisition, and International Strategies - Essay Example The company under consideration is the Burger King. It also identifies a possible business level and corporate level strategies for the organization. The American Airline Group is a company that is publicly traded and has its headquarters in Texas. This company was formed on the 9th of December 2013, with a merger between the United States Airways Group, and the AMR Corporation. These two airline companies merged to form the largest airline company all over the world. The American Airline Group operates not less than 6,700 daily flights to different locations in the world. This covers about 56 countries, and more than 336 locations found in these 56 countries (Agyenim, 2014). The American airline group has operating revenue of about 40 billion American dollars, and boasts of a workforce of over 100,000 employees. The company plans to introduce an additional 607 aircrafts, and this includes 90 wide body airplanes, and 517 narrow body airplanes. The full merger of this company, resulting to the use of a single operating certificate is expected to be complete in the later periods of 2015 (Agyenim, 2014). The merger of the two airline companies was necessitated by the bankruptcy of AMR group. The strategy used in creating this merger is referred to as the stock-swap strategy/merger. Under this strategy, the shareholders of the US Airways received 28% of the shares of the new company. The creditors of AMR, and other equity holders were to receive the remaining 72% of the shares of the new company. This process was to take two years, upon which the company will pay the creditors of AMR their interests, and other stakeholders of the company a share of the company equity (Agyenim, 2014). This is a rare occurrence in bankruptcy cases where creditors usually receive cents, on a dollar they claim. On the other hand common stakeholders of the company are always wiped out, without receiving any benefits from the

Reading Response Questions for One.Life 8 & 9 Essay

Reading Response Questions for One.Life 8 & 9 - Essay Example In my view, the church is the perfect place to worship and pray. In addition, the church makes Christians have the desire to know more about the old devotional traditions of the Christian faith, and to become fully engaged in their renaissance today. There are various strengths and weaknesses in the church. Some of the strengths include the church enabling people explore how Jesus Christ prayed, how various denominations pray (Orthodox Christians, Anglicans and Roman Catholics) and how the Psalms teach Christians to pray. Other strengths of the church is empowering believers and making them understand that praying as a church is an important part of spiritual formation. The main weakness of the church is incorporating modernity into worship whereby God is no longer given the due respect as He was being given in the early church during the time of apostles of Christ. If I were in the capacity to change, I would ensure that every single believer follows the word of God to later, remaining holy since God is Holy. Chapter 9 of the book covers the life that believers lead in their ministry of serving God. According to the chapter, believers need to live a committed and dedicated life; however, they later get it hard to maintain the committed life (McKnight, 2010). The main reason as to why believers fail to maintain the life is the mixing of money and possessions with the church. I agree with the chapter since it speaks of the practical life that believers face every day. The chapter strikes me when it introduces the issue of leading a committed life and mixing possession and money with the church; something that drifts believers (me, for that matter) away from Jesus. There are various reasons that make people find the committed life difficult to follow. Such reasons include peer pressure whereby a believer with non-believer friends would be swayed away. In addition, some people have the

Dents Disease: Symptoms, Genetics, and Treatments

Dents Disease: Symptoms, Genetics, and Treatments Dents Disease Alessander Leyendecker Junior Clinical Aspects Dents disease is a recently characterized syndrome caused by a genetic mutation that leads to a renal tubular disorder and is characterized by manifestations of proximal tubule dysfunction. The proximal tubule is responsable for the reabsorption of sodium, potassium, calcium, glucose and low-molecular-weight proteins (like retinol binding protein and ÃŽ ±1 microglobulin and ÃŽ ²2 microglobulin) and for the secretion of ammonia, toxins, drugs and H+. Therefore, a proximal tubule dysfunction like Dents disease is characterized by low-molecular-weight proteinuria (excretion of low-molecular-weight proteins in the urine), hypercalcinuria (high concentration of calcium in the urine), nephocalcinosis (deposition of calcium salts in the renal parenchyma), nephrolithiasis (formation of crystalline aggregates that can develop anywhere along the urinary tract) and progressive renal failure. Low-molecular-weight proteinuria represents the most common symptom of Dents disease (Devuyst Thakker, 2010). Mapping: A higher disease severity in males and a lack of male to male transmission were identified by an analysis of 5 unrelated British families. The fact that females may show a milder phenotype suggests an X-linked recessive inheritance. The locus position on chromossome Xp11 was identified by linkage analysis of 2 3-generation families with Dent disease by Pook et al. (1993). Twenty X-linked polymorphic markers were used and the Linkage was established between Dents disease and the Xp1l 1 loci ARAFI (Z max = 5.42, 0 = 0.000), DXS426 (Z max = 3.61, 0 = 0.000), DXS255 (Z max = 5.48, 6 = 0.000) and DXS988 (Z max = 4.25, 0 = 0.045) to determine a locus order. In addition, DXS255 has presented a microdeletion in the affected members of one family, allowing the localization of Dents disease to Xp11.22 (Pook et al., 1993). Furthermore, another proximal renal tubular disorder associated with nephrolithiasis in a North American family and referred to as X-linked recessive nephrolithiasis has also been mapped to Xpl1.22. Suggesting that maybe there is one gene causing both X-linked recessive nephrolithiasis and Dents disease. Molecular Genetics: A study conducted by Fisher et al (1994) found a microdeletion in one Dent’s disease kindred, allowing the identification of the gene CLCN5 as a candidate. Furthermore, an investigation of 11 kindreds with renal tube disorders indentified 3 nonsense, 4 missense, 2 donor splice site mutations, 1 intragenic deletion and 1 microdeletion in CLCN5 gene (Llyod et al., 1996). Furthermore, Hoopes et al. (2005) indentified that some patients with Dents disease suffer from extra-renal symptoms such as cataract, mild intellectual impairment and hypotonia. Shared mutations in OCRL1 with the oculo-cerebrorenal syndrome of Lowe were identified in these patients. The presence of such extra-renal symptoms with mutations relating to Lowe syndrome is known as Dent disease 2. A research conducted by Bà ¶kenkamp et al. (2009) showed that low-molecular-weight proteinuria was a constant feature in all both Dent disease 1, Dent disease 2 and oculo-cerebrorenal syndrome of Lowe. However, there was a wide overlap in most of the other symptoms of the proximal tubulopathy. Nephrocalcinosis was observed more frequently in patients with Dents disease 1 than those with Dents disease 2 and Lowe syndrome; aminoaciduria, renal tubular acidosis, and renal failure was observed more frequently in patients with Lowe syndrome than patients with Dent-disease 1 and Dent disease disease 2. Genetics: All these findings have demonstrated that both Dent disease 1 and Dent disease 2 are a X-linked recessive inherited condition, caused by mutations in the OCRL1 (Dent disease 2) or CLCN5 (Dent disease 1) genes. These genes are located on chromosome Xp11.22 (Dent disease 1) and Xq25 (Dent disease 2). Mutation in CLCN5 are responsible for about 60% of the cases of Dent disease and mutation in OCRL are responsible for about 15% of the cases of Dent disease (Hoopes et al., 2004). So, nearly 25% of the cases of Dent disease do not have a known disease-causing mutation in OCRL or CLCN5, implying another genetic heterogeneity. Due to the fact that Dents disease is a X-linked recessive disorder, the disease is generally found in males only. Females carriers may show a milder phenotype. Furthermore, the disease may be present in early childhood (Devuyst Thakker, 2010). To date around 250 families with Dent-1 disease and about 50 patients with Dent-2 disease have been reported (Ludwig, Levtchenko Bà ¶kenkamp, 2014). The diagnosis of Dents disease is always difficult due to the wide variability of clinical presentation and, occasionally, lack of family history. Therefore, the disorder is likely underdiagnosed and the prevalence of this disease in the population is still unknown. More than 200 Dents disease 1 patients withCLCN5defects have been described with several different disease-causing mutations all over the gene. The types of mutations includes missense (44%) and nonsense (26%) mutations, small deletions/insertions (15%) and splice defects (11%), with a few hotspots, usually affecting arginine codons. Large insertions/deletions can be detected in around 4%of the patients. However, OCRLmutations in Dents disease 2 patients are not uniformly distributed. Missense mutations are usually found in exons 8–15 while nonsense or frameshift mutations very often affect exons (Ludwig, Levtchenko Bà ¶kenkamp, 2014). CLCN5 encodes the electrogenic Clà ¢Ã‚ Ã‚ »/H+ exchanger ClC-5. OCRL1 encodes a phosphatidylinositol bisphosphate (PIPà ¢Ã¢â‚¬Å¡Ã¢â‚¬Å¡) 5-phosphatase and mutations are also linked to the Lowe Syndrome. Mutations in any of these genes can culminate in the lack or dysfunction of these important proteins and result in the phenothype of Dents disease. Pathophysiology: The ability to reabsorb low-molecular-weight proteins and albumin that are ultrafiltered by the glomerulus are characteristics of the epithelial cells covering the proximal tubule portions of the nephron. This ability involves a process called receptor-mediated endocytosis. In the receptor-mediated endocytosis the particle to be endocytosed binds to specific receptor proteins concentrated at certain locations in the plasma membrane. Several types of receptors participate in the receptor-mediated endocytosis. These sites form a small depression in the plasma membrane that is covered by clathrin (a type of fibrous protein). After the binding of a ligand to plasma membrane-spanning receptors, a signal is sent through the membrane, leading to membrane coating, accumulation of the ligands into coated pits, and formation of a membrane invagination. The receptor and its ligand are then opsonized in clathrin-coated vesicles. The clathrin confers stability to the vesicle that are being transp orted into the cell. In the cytoplasm the vesicle loses its clathrin coverage and individual vesicles fuse to early endosomes. The acidification of endosomes by proton pumps ATP-dependent leads to the dissociation of the protein-receptor complex. This process allows the endosomes to fuse with the lysosomes through late endosomes. This acidification is reached by ATP-mediated transport of cytosolic H+ through the V-ATPase and demand an equal Cl conductance to preserve electroneutrality. It has been theorized that the H+ gradient can be neutralized by the C1C-5 action. In theory, ClC-5 provides an electrical shunt to neutralize the H+ gradient. Therefore, the vesicular acidification should be impaired by the loss of the endosomal Cl conductance mediated by ClC-5, resulting in the dysfunction of proximal tubule cells. To confirm this hypothesis, Piwon et al. (2000) created two distinct strains of ClC-5 knock-out (KO) mice which both have symptoms of the main characteristics of Dentâ₠¬â„¢s disease including manifestations of proximal tubule dysfunction like low-molecular-weight proteinuria. A reduced acidification of early endosomes in ClC-5-deficient mice have been demonstrated by in vitro experiments. However, ClC-5 is a 2Cl/H+ exchanger and not just a Cl channel, so the importance of this exchange activity for Dent’s disease was still unknown and needed to be assessed. In order to investigate this relevant question, Novarino et al. (2010) created a knock-in (KI) mouse presenting a point mutation in a important glutamate residue which transforms the exchanger into an uncoupled Cl channel that should help the endosomal acidification. The conventional ClC-5 KO mouse was subsequently compared with the KI mice. Acidification of the renal endosomes from wild-type and KI mice was regular, but greatly impaired in KO mice. Nevertheless, the same symptoms were indentified in both KI and KO mice, despite normal endosomal acidification and patients with Dentâ€⠄¢s disease, including low-molecular-weight proteinuria, hypercalciuria and hyperphosphaturia. Moreover, both the KI and KO mouse presented impaired proximal tubule endocytosis, indicating that proximal tubule dysfunction in Dent’s disease may happen in spite of the regular acidification of the endosomes. These findings indicate a function for a diminished endosomal Cl accumulation in Dent’s disease. Diagnosis: The clinical diagnosis of Dent’s disease is grounded on the presence of low-molecular-weight proteinuria, hypercalciuria, and at least one of the following characteristics: kidney stones, hematuria, nephrocalcinosis, renal insufficiency or hypophosphataemia (Hoopes et al., 2004). The clinical diagnosis can also be supported by nephrolithiasis and/or history of X-linked inheritance of renal Fanconi syndrome. The diagnosis can be confirmed by the recognition of mutation in both CLCN5 or OCRL1 by sequence analysis. Sequence analysis of affected males allows the identification of whole-gene deletions, multiexonic and exonic due to the lack of amplification is this case. Confirmation may also require deletion/duplication studies. It is imperative to previously identify the disease-causing mutation in the family when conducting a carrier test for at-risk relatives. The diagnosis of Dent disease 2, related with OCRL1 mutations, is more common than a diagnosis of Lowe syndrome when th ere are an absence of clinical symptoms and lack of severe intellectual deficit. Treatment: The reduction of hypercalciuria, prevention of nephrocalcinosis and kidney stones, and retardate the evolution of chronic kidney disease (nephrolithiasis) are the objectives of the current treatment. Thiazide diuretics in doses higher than 0.4 mg/kg/day have reducted urinary calcium excretion by more than 40% in males with Dent disease (Raja et al., 2002). However, side effects like hypokalemia, volume depletion, and cramping often occur. Similarly, we need to be cautious due to the fact that an increased hypercalciuria can result from the treatment of rickets with vitamin D. Furthermore, recent studies has been shown that a high citrate diet can slow the progression of chronic kidney disease in CLCN5 knockout mice (Cebotaru et al., 2005) and can be efficiently used to treat Dent disease. Genetic Counseling: The two types of Dent’s disease are X-linked. Therefore, men are affected more harshly. The father of an affected man will not have the disease or will he be a carrier of the mutation. The probability of transmitting the disease allele in each pregnancy is 50% if the mother of the proband is a carrier. Males who inherit the mutation will be affected and females who inherit the mutation will be carriers and will generally not be strongly affected. Affected men pass the disease-causing mutation to all of their daughters (who become carriers) and none of their sons. It is possible to conduct carrier testing for at-risk female relatives and prenatal testing for pregnancies at increased. Word count: 1673 References Blanchard A, Vargas-Poussou R, Peyrard S, Mogenet A, Baudouin V, Boudailliez B, Charbit M, Deschesnes G, Ezzhair N, Loirat C, Macher MA, Niaudet P, Azizi M: Effect of hydrochlorothiazide on urinary calcium excretion in Dent disease: an uncontrolled trial. Am J Kidney Dis 2008, 52:1084-1095. Bà ¶kenkamp A, Bà ¶ckenhauer D, Cheong HI, Hoppe B, Tasic V, Unwin R, Ludwig M. (2009). Dent-2 disease: A mild variant of Lowe Syndrome. J. Pediatr, 155, pp. 94-99, ISSN 0022-3476 Cebotaru V, Kaul S, Devuyst O, Cai H, Racusen L, Guggino WB, Guggino SE: High citrate diet delays progression of renal insufficiency in the ClC-5 knockout mouse model of Dent’s disease. Kidney Int 2005, 68:642-652. Devuyst, O., Thakker, R. V. (2010). Dent’s disease. Orphanet Journal of Rare Diseases. Fisher, S. E., Black, G. C., Lloyd, S. E., Hatchwell, E., Wrong, O., Thakker, R. V., Craig, I. W. (1994). Isolation and partial characterization of a chloride channel gene which is expressed in kidney and is a candidate for Dents disease (an X-linked hereditary nephrolithiasis). Human molecular genetics, 3(11), 2053-2060. Hara-Chikuma M, Wang Y, Guggino SE, Guggino WB, Verkman AS: Impaired acidification in early endosomes of ClC-5 deficient proximal tubule. Biochem Biophys Res Commun 2005, 329:941-946. Hoopes, R. R., Raja, K. M., Koich, A., Hueber, P., Reid, R., Knohl, S. J., Scheinman, S. J. (2004). Evidence for genetic heterogeneity in Dents disease.Kidney international,65(5), 1615-1620. Hoopes RR Jr, Shrimpton AE, Knohl SJ, Hueber P, Hoppe B, Matyus J, Simckes A, Tasic V, Toenshoff B, Suchy SF, Nussbaum RL, Scheinman SJ. Dent Disease with mutations in OCRL1. Am J Hum Genet. 2005;76:260–267. doi: 10.1086/427887. Ludwig, M., Levtchenko, E., Bà ¶kenkamp, A. (2014). Clinical utility gene card for: Dent disease (Dent-1 and Dent-2).European Journal of Human Genetics. Lloyd, S. E., Pearce, S. H., Fisher, S. E., Steinmeyer, K., Schwappach, B., Scheinman, S. J., Thakker, R. V. (1996). A common molecular basis for three inherited kidney stone diseases. Nature, 379(6564), 445-449. Novarino G, Weinert S, Rickheit G, Jentsch TJ: Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis. Science 2010, 328:1398-1401. Pagon, R. A., Adam, M. P., Bird, T. D., Dolan, C. R., Fong, C. T., Stephens, K., Rossetti, S. (2012). Dent Disease. Piwon N, Gunther W, Schwake M, Bà ¶sl MR, Jentsch TJ: ClC-5 Cl-channel disruption impairs endocytosis in a mouse model for Dent’s disease. Nature 2000, 408:369-373. Pook, M. A., Wrong, O., Wooding, C., Norden, A. G. W., Feest, T. G., Thakker, R. V. Dents disease, a renal Fanconi syndrome with nephrocalcinosis and kidney stones, is associated with a microdeletion involving DXS255 and maps to Xp11.22. Hum. Molec. Genet. 2: 2129-2134, 1993. Raja KA, Schurman S, DMello R G, Blowey D, Goodyer P, Van Why S, Ploutz-Snyder RJ, Asplin J, Scheinman SJ. Responsiveness of hypercalciuria to thiazide in Dents disease. J Am Soc Nephrol. 2002;13:2938–44 Wrong.O.M., Norden.A.G.W. and Feest.T.G. (1990) Quart. J. Med. 77, 1086-1087.

William Shakespeares Othello Essay -- William Shakespeare Othello Ess

William Shakespeare's Othello Every artist needs a subject to draw inspiration from—an idea to develop into a masterpiece. Leonardo da Vinci had Madame Lisa to portray in paint. The Beach Boys had Rhonda to render in rhyme. And William Shakespeare had one of one hundred stories written by Giraldi Cinthio to help him create his masterpiece, Othello. Each artist creates his own interpretation from his source. Shakespeare transformed the core of Cinthio’s story into a tragedy. A tragedy is drama which depicts â€Å"a public struggle between larger-than-life protagonists and universal forces† (Glossary 175). A tragedy also involves a â€Å"hero’s suffering and his consequent moments of tragic insight or knowledge† (McJannet 1). Each subtle change, which Shakespeare adapts from his source, serves to turn an ordinary tale into an extraordinary tragedy. The changes Shakespeare makes create a â€Å"larger-than-life protagonist.† In Cinthio’s work, the Ensign falls in love with Disdemona. The Ensign tries every means available to woo her, yet he fails in every attempt. The Ensign â€Å"imagined that the cause of his ill success was that Disdemona loved the Captain of the troop† (Cinthio 137). As a result, â€Å"the love which [the Ensign] had borne the lady now changed into the bitterest hate, and†¦he devoted all his thought to plot the death of the Captain of the troop and to divert the affection of the Moor from Disdemona† (Cinthio 137). Cinthio’s plot does not center on Othello, it is powered by Disdemona. Shakespeare makes a key change when creating his play. Shakespeare makes Othello the clear protagonist. Iago’s plotting revolves around Othello. Not only does Othello pass Iago over for a rightly deserved position, but â€Å"it is thought a... ...Michelangelo did with a chisel, so Shakespeare does with a pen. Shakespeare took Cinthio’s idea of a Moor. Shakespeare chipped away parts, and patched them back together, in a reconfiguration from his own mind’s eye. Shakespeare creates a tragic flaw, and from this a tragic error occurs. Shakespeare creates an impressive protagonist amid a fateful world. Within this tragic world, the fatal manipulation of Othello is brought to light. In short, Shakespeare turns a tale into a tragedy and a story into a masterpiece. Works Cited: Cinthio, Giraldi. Hecatommithi. Trans. J. E. Taylor. Ed. Alvin Kernan. New York: New American Library, 1998. (134-146). Glossary. (170-175). McJannet, Dr. Linda. â€Å"Short Paper: Shakespeare and Cinthio.† Spring, 2006. (1-2). Shakespeare, William. Othello. Ed. Alvin Kernan. New York: New American Library, 1998. (2-128).

Distribution Plan Essay

The distribution and delivery section of LEAPh Incorporation aims to satisfy and create values for the customers in which the company operates. The distinguishing characteristics of the business will be the combination of management experience, sales and distribution experience, high quality, innovative products and exceptional customer service. In particular, the Leading Philippines Incorporation will do a full service distribution servicing the customers in the market with a fulfilling assistance. In addition, the LEAPh Inc. will have an exclusive contract to distribute a new, groundbreaking product that would enable the company to gain immediate access to a majority of the potential customer base. The LEAPh Inc. intends to become a recognized distributor of one of a kind Digital Single-Lens Reflex Camera (DSLR) in the Philippines and become an internationally known locale brand. Leading Philippines Inc. plans to develop strong relationships with key customers so that the company will be viewed as an indispensable partner, rather than just another manufacturer. The company will work closely with each customer to recommend product assortment unique for their retail base, appropriate stocking levels, pricing and display assortments, as well as promotional ideas and material to increase sales. The LEAPh will seek out and work with the retailers that represent to deliver the most innovative and exciting products possible to the customers that will be served. In order for the products to be received by the customers, the LEAPh will be going to distribute the cameras through sales representatives and through retail stores as well. The company will be using a three level distribution channel. In a three level channel structure, the retailers serve as intermediaries between the consumers and the manufacturer which is the LEAPh. Retailers order products directly from the manufacturer, and then sell those products directly to the consumers. This will enable the company to stay in touch with the retailers up to the end users of the products and understand their tastes, preferences and tendencies. This will also help the company to minimize the total distribution costs for the given products. MANUFACTURER RETAILERS CUSTOMERS Leading Philippines Inc. Department Stores Customers The intermediaries which are the retailer’s outlets provide several benefits to both manufacturers and consumers. It will improve the efficiency of the company; make a better assortment of products, the reutilization of transactions, and easier searching for goods as well as customers. The use of this level of distribution will also aid the search processes of both the buyers and sellers. Producers are searching to determine their customers’ needs, while customers are searching for certain products and services. A degree of uncertainty in both search processes can be reduced by using this channel of distribution. For example, consumers are more likely to find what they are looking for when they shop at retail institutions organized by separate lines of trade, such as grocery, hardware, and clothing store. In addition, producers can make some of their commonly used products more widely available by placing them in many different retail outlets, so that consumers are more likely to find them at the right time. The company will be implementing an individualized customer service which will provide the customers with what they want, when and how they want it with the help of the retailers. This fully integrated program for the customers will help the company to increase its sales through innovations of the products, creating promotions, advertising, custom marketing material and the word of mouth from its customers. In this way, the company has the full control over the distribution of the products as well. Here are the methods that will be used in this level of channel distribution of the products from Leading Philippines Inc.: †¢ Selling of products through the leading retail outlets and department stores nationwide. †¢ Selling the products by the orders that are received by telephone, email and fax which is also known as telemarketing. ( Made possible by advertising the products through websites) This stage of distribution channel will also be use in order for the products to be widely available in all leading department stores and retailer’s shops nationwide. And to optimize the product launch as well. The LEAPh will employ an intensive distribution to the customers so that the products could be distributed from as many department stores and retailers ‘outlets as possible to provide a location convenience for its consumers. It will also increase the sales of the company, and provide wider customer recognition. By communicating and building relationships with the members at each step in the channel, there should be a proper communication throughout the channel and every member in the channel should contribute for a healthy relationship. Transparency should be maintained throughout the channel.

Selling organs on the black market - 1081 Words

Selling Organs on the Black Market Every teenager wants to own the newest iPhone or iPad but to save up for those working at the local McDonald’s it would take some time. But in China, you can get it just by selling a kidney. In face according to a BBC news article dated April 6, 2012 five people were arrested for convincing a teenager to sell his kidney in an online chat room for the equivalent of $3,000. The teenager is now suffering from kidney failure, and just for a couple of new toys. The New York Times states on June 29, 2012 that only 10% of the global needs for organ transplantation are being met. The UK Telegraph of May 28, 2012 states that experts are saying that a rise in diabetes and other diseases has led to the†¦show more content†¦There is only one country that allows the legal buying and selling of organs, Iran allows people to sell and buy kidneys under the state regulated surveillance of two non-profit organizations but Iranians are not allowe d to sell kidneys to non-citizens. Now that we have discussed both the problems and the causes of the black market organ trade, let’s focus on two possible solutions we could implement. First we well discuss a possible opt out policy, and then we will look at enforcing and implementing laws. Let’s begin with a possible solution is to activate an opt out policy in each state. Richard Brodsky wants to change the way the New York organ donation system works. He believes that this system could help increase organ and tissue donations. The proposal would require that people be automatically added to the state donor registry unless they opt out when they get a driver’s licenses or state identification card. Richard says his bill has sparked a lot of interest but that he knows both individuals and religious groups have raised concerns. Mary baily a member of the Hastings Center, stated that it’s easy to see this would not go over well with Americans at a t ime when many are pushing against government control on a variety of other issues. UCLA professor and medical doctor, Gabriel Danovitch testified before the U.S. House of Foreign Affairs in 2012 that there are several things the U.S. government can do. He begins by stating that the National organShow MoreRelatedThe Ethical And Medical Controversy1413 Words   |  6 PagesThe argument regarding the selling of organs on the black market has been an ethical and medical controversy for decades. The problems that exists ethically is to be believed that putting a price on a human organ is materialistic, people may go to extremes to donate a kidney, and the fear of the spread of infections or diseases. Although the fears are natural, mostly because people have always associated the black market with a negative connotation, the ethical fears out-weigh the idea that donatingRead MoreOrgan Selling And An Elderly Man Sits Patiently1531 Words   |  7 PagesOrgan Selling Peering into the window of Da Vita dialysis, an elderly man sits patiently. His patience is not from the fact that he has no place to go afterwards; his schedule was clear. His patience came from the fact that he can bare the wait in the room, because he knows down the hall the nurse will be re-puncturing his forearm to administer the hemodialysis. It was his third time coming in this week, which meant he wouldn t be back until next week. Of course, when he looks at the bruising onRead MorePros and Cons for Paying Organ Donors1534 Words   |  6 Pagesdonations, compared to other organs donations, is that each person is born with two and can sustain a healthy life with just one; simple facts such as this is what has driven the black market kidney trade to flourish. (CBSNEWS) However, if this is the case then why aren’t more people donating? Is it because they are not getting something in return? Why donate for free when someone on the black market will pay 10,000 dollars? The main arguments against black market organ donations, not limited toRead MoreThe Trafficking Of Human Organs1564 Words   |  7 PagesTrafficking Human Organs The trafficking of human organs is on the rise and black market operations are happening under everyone’s nose. Currently there are more than 120,000 people who are on the waiting list for a lifesaving organ. Among these people waiting for their transplant approximately twenty-five people will die each day waiting for their number to come up (Perry, 2016). According to the World Health Organization there is only about ten percent of organ transplants being met through theRead MoreFinancial Incentives on Organ Donation1582 Words   |  7 PagesMore than 100,000 men, women and children in need of life-saving organ transplants, every 10 minutes another person is added to the national organ transplant waiting list and averages of 18 people die each day from the lack of available organs. (donatelife.net) Organ transplants are very important because they replace the damaged organ and help the body function once again. There are still huge shortages of organs, even after awareness and other ways of educating the public. Some Americans are openRead MoreEssay on Organ Donation1638 Words   |  7 Pagescurrent process of procuring organs for transplantation. It will also explore technology on the horizon and alternates to donation. The waiting list for transplant surgery far exceeds the current supply. Black Market organ trade in this, as well in foreign countries is alive and well. Donation is not able to keep up with demand. We have to take measures to ensure those in the most need are taken care of. We already allow people to sell eggs, sperm and blood why not other organs? I will attempt to showRead MoreThe Problem Of Organ Donation1338 Words   |  6 Pagesthemselves dying with the decrease of organ donates. Randy Creech finds himself in need of new heart but has been place on long waiting list. Randy has been waiting for months just waiting to found a match but like many others they find themselves dying before getting their match. There been talk betwe en doctors on should them be compensation for organ donates but what would the price be. Should Randy be able to go buy heart from a different country or black market to keep himself alive. So the questionRead MorePersuasive Essay On Organ Donation1371 Words   |  6 PagesOrgans found on the black market are often taken from the body of an unwilling victim. People going about their business abducted and violated to make some extra cash, which could be obtained legally if compensation for donors were legal. In 2005, about one thousand two hundred people died waiting for a kidney transplant, something that could have been prevented if only there wasn’t an organ shortage. The shortage of organs can be tied to the financial devastation that organ donors often succumbRead MoreIllegal Sale Of Human Organs1031 Words   |  5 PagesSale of human organs have been illegal in the U.S. since the National Organ Transplant Act of 1984 was established, but illegal sale of organs still ex ist on the black market. The black market is where desperate wealthy people can make contact with unscrupulous greedy criminals to secure themselves a kidney or any other type of human organ they may need. The idea that a person’s organ can be purchased online or through a dealer like a car is unethical and objectionable. Potential causes for the thrivingRead MoreSale Of Organs And Its Effects On Society1417 Words   |  6 PagesSale of Organs An organ is a body tissue that helps in the general operation of the body. Selling organs is legally and morally wrong. However, some people still do that. Therefore, I believe that The law should ban people from selling their organs because each person was born with their organs. It is like property that the person should take care of. Also, organs buyers usually take advantage of the poor and weak people. I am against selling organs by all means for a number of reasons such as, the